To make the base, combine the graham cracker crumbs, Brie cheese, dried cranberries, sugar, and melted butter in a food processor and pulse until well combined.
Press the mixture into a 9-inch springform pan and bake for 10 minutes. Remove from the oven and set aside to cool.
To make the filling, beat the cream cheese, sugar, whiskey, and vanilla extract in a large bowl until smooth. Add the eggs one at a time, beating well after each addition. Stir in the melted chocolate chips.
Pour the filling over the cooled crust and bake for 50-60 minutes, or until the center is set. Remove from the oven and allow to cool to room temperature.
To make the topping, combine the chopped macadamia nuts, brown sugar, and melted butter in a small bowl and mix well. Spread the mixture over the top of the cooled cheesecake.
Chill the cheesecake in the refrigerator for at least 4 hours before serving.