To make the crust, combine Graham cracker crumbs, sugar, and melted butter in a bowl and mix until well combined. Press mixture into the bottom of a 9-inch springform pan and bake for 10 minutes. Remove from oven and set aside to cool.
To make the filling, using an electric mixer, beat softened cream cheese until smooth. Add Greek Yogurt, honey, eggs, and vanilla extract; mix until fully combined. Pour filling over the cooled crust.
Bake for 45-50 minutes or until cheesecake is set and center is slightly jiggly. Allow to cool to room temperature, then refrigerate for at least 4 hours, preferably overnight.
Before serving, prepare the topping by combining sliced blood oranges, grapefruits, and honey in a small bowl. Arrange fruit over the top of the cheesecake.